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Job IDEmployerPositionDescriptionRequirementsLocationContactPost Date
Details>> Flexus Biosciences
Senior Research Associate, Bioanalytical/DMPK
The successful candidate will be responsible for the design of a broad range of small-molecule bioanalytical methods and the corresponding sample analysis from in vivo (PK and PD) and in vitro ADME assays, including quantitation and analysis of PK results and in vitro assays to support small molecule preclinical research. Flexus Biosciences is an exciting new company founded on the vision of creating new cancer therapeutics through the innovative application of unexploited insights in immunology. The company was recently formed by a group of seasoned researchers from the biotechnology and pharmaceutical industries, supported by one of the nation’s premier life sciences venture capital firms. Flexus Biosciences offers a competitive compensation and benefits package, including aggressive participation in the growth of the company in the form of stock option grants.
Candidates should have experience in data acquisition and analysis of samples from a variety of biological matrices. The ideal candidate will have at least 5 years of experience in AB Sciex LCMS/MS operation in an industrial setting and the ability to perform routine maintenance and minor instrument trouble-shooting. The role demands a highly goal-driven approach and the ability to focus on time-sensitive objectives. The candidate should also enjoy operating in an exceptionally dynamic and cooperative environment where every voice matters.
San Carlos, CA (San Francisco Bay Area)
careers@flexusbio.com
9/12/2014 9:13:41 PM
Details>> MyoKardia, Inc.
Senior Scientist - Analytical Chemistry
Responsible for evaluating, developing, implementing and qualifying/validating all analytical methodology for raw materials, drug substances (APIs), and finished products of the Company’s development projects. Assessing needs at different stages: develops appropriate methods suitable at each phase of drug development; leads the method development and optimization effort as well as method transfers internally and externally; proactively seeks improvement in the existing methods. Responsible for supporting formulation development, API and drug product in process tests and release tests. ESSENTIAL DUTIES AND RESPONSIBILITIES: • Develops, executes, and troubleshoots methods for raw materials, drug substance and finished products • Develops analytical methods in support for manufacturing process optimization and formulation development • Designs and coordinates method transfer to other departments and/or external vendors • Establishes and manages relations with external vendors/consulting firms, other research facilities and consultants supporting development projects and technology transfer • Proactively and independently identifies development problems and generates a study plan/protocol to address these problems. Summarizes experimental results in appropriate documents and presents the results internally and/or externally • Drives analytical development activities forward by improving methods, processes, and operations, using creative problem solving skills • Troubleshoots and maintains analytical instruments • Prepares SOPs, protocols, technical reports and appropriate CMC sections in INDs and NDAs to support regulatory submissions • Contributes to scientific literature and conferences and can contribute to intellectual property generation. • Recruit, supervise and develop junior analytical scientists • Provides budgetary inputs
• PhD in Analytical Chemistry or related discipline with at least 5 years of relevant experience or BS/MS with minimum 10 years of relevant experience in the biotechnology or pharmaceutical industry • Working knowledge of cGMP practices, ICH Quality Guidelines and US/EU regulatory requirements • Hands-on experience in more than one of the following techniques is a must: IC, HPLC, UPLC, GC, GPC/SEC • Excellent analytical problem solving capability • Ability to work in fast-paced environment • Self-motivated, detailed oriented with good organizational skills, possess good oral and written communication skills as well as the ability to thrive in an independent and a collaborative team environment MyoKardia’s mission is to revolutionize the treatment of genetic heart disease. The company’s proprietary platform combines recent breakthroughs in muscle biology with leading-edge cardiovascular disease genetics. This personalized, genetically targeted approach focuses on the underlying cause of disease and has the potential to drastically improve the treatment of cardiomyopathies, and ultimately a broader spectrum of cardiovascular disease, including heart failure. Founded by world leaders in muscle biology and cardiovascular disease genetics, MyoKardia was launched in 2012 with funding from leading life sciences investor, Third Rock Ventures. Please send resume to myocareers@myokardia.com and reference “Senior Scientist – Analytical Chemistry” in the subject line. See our website for additional information about the company: wwww.myokardia.com.
South San Francisco, CA
Please send resumes to myocareers@myokardia.com and reference “Senior Scientist – Analytical Chemistry” in the subject line
9/11/2014 10:07:48 AM
Details>> Genentech
Scientist - Preclinical and Translational Pharmacokinetics/Pharmacodynamics (PTPK)
Passionate About Science We’re passionate and rigorous about our science. For more than 30 years, Genentech has been at the forefront of the biotechnology industry, using innovative science to develop breakthrough medicines that improve the lives of people with serious or life-threatening diseases. The following opportunity exists in our South San Francisco, CA headquarters: Scientist - Preclinical and Translational Pharmacokinetics/Pharmacodynamics (PTPK) Responsibilities: The Preclinical and Translational PKPD (PTPK) Department at Genentech, Inc. is seeking a PhD level scientist who is driven to understand pharmacokinetics (PK) and pharmacodynamics (PD) of novel drug candidates. The candidate will be responsible for investigating the pharmacokinetics, biodistribution, and PKPD relationships of novel therapeutics in preclinical models to identify lead candidates for further development, and for bridging preclinical PKPD information to patients. The candidate will be working in close partnerships across various functions including Research, Development Sciences, Clinical Sciences, Biostatistics, and Regulatory. The candidate will represent the department on cross- functional project teams as a PKPD representative and present PKPD results at cross-functional teams, department meetings, review committees, and conferences.
Genentech is seeking individuals who are inspired by our mission and who would fit in well with the collaborative, rigorous and entrepreneurial spirit of the company culture. Candidates must have a Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Biomedical Engineering or related discipline. 5+ years of experience (post-doctoral experience included) and demonstrated impact on drug development and/or the PKPD scientific landscape is also required. Passionate About Our People We recognize that our people are our most important asset. It’s why we foster an inclusive environment that encourages diversity and offer competitive healthcare and benefits to help you bring the best to the business and to your personal life. Join us as we continue to tackle medicine’s most challenging problems and live a life inspired. Apply Below! Now a member of the Roche Group, Genentech has multiple medicines on the market for cancer and other serious illnesses. Genentech is an Equal Opportunity Employer: Minorities/Women/Disability/Veteran. Apply Here: http://www.Click2apply.net/z4vvrs7
South San Francisco, California, 94080
Human Resources
9/10/2014 7:47:49 AM
Details>> Genentech
Associate Scientist/Scientist: Preclinical & Translational Pharmacokinetics (Modeling and Simulation)
Passionate About Science We’re passionate and rigorous about our science. For more than 30 years, Genentech has been at the forefront of the biotechnology industry, using innovative science to develop breakthrough medicines that improve the lives of people with serious or life-threatening diseases. The following opportunity exists in our South San Francisco, CA headquarters: Associate Scientist/Scientist: Preclinical & Translational Pharmacokinetics (Modeling and Simulation) Responsibilities: The Preclinical and Translational PKPD (PTPK) Department at Genentech, Inc. is seeking a PhD level scientist who is driven to understand pharmacokinetics (PK) and pharmacodynamics (PD) of novel drug candidates. The successful candidate will have responsibilities for designing and conducting PKPD analysis to support drug design and selection, preclinical research and data interpretation, and translational PKPD analysis to support Phase I trial planning. The candidate will be working in close partnerships across various functions including Research, Development Sciences, Clinical Sciences, Biostatistics, and Regulatory. The candidate will represent the department on cross- functional project teams as a PKPD representative and present PKPD results at cross-functional teams, department meetings, review committees, and conferences.
Requirements: A Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Biomedical or Chemical Engineering, or a related discipline and a proven track record of applying modeling and simulation approaches to PKPD and drug development either in industry and/or academia is required. 3+ years of experience (post-doctoral experience included) and demonstrated impact on drug development and/or the PKPD scientific landscape. Passionate About Our People We recognize that our people are our most important asset. It’s why we foster an inclusive environment that encourages diversity and offer competitive healthcare and benefits to help you bring the best to the business and to your personal life. Join us as we continue to tackle medicine’s most challenging problems and live a life inspired. Apply Below! Now a member of the Roche Group, Genentech has multiple medicines on the market for cancer and other serious illnesses. Genentech is an Equal Opportunity Employer: Minorities/Women/Disability/Veteran. Apply Here: http://www.Click2apply.net/qxp9j6x
South San Francisco, California, 94080
Human Resources
9/10/2014 7:40:31 AM
Details>> Genentech
Scientist, Quantitative Systems Pharmacology (PKPD)
Passionate About Science We’re passionate and rigorous about our science. For more than 30 years, Genentech has been at the forefront of the biotechnology industry, using innovative science to develop breakthrough medicines that improve the lives of people with serious or life-threatening diseases. The following opportunity exists in our South San Francisco, CA headquarters: Scientist, Quantitative Systems Pharmacology (PKPD) Responsibilities: The Preclinical Translational PKPD Department at Genentech, Inc. is seeking a Quantitative Systems Pharmacology Modeling & Simulation Scientist who is driven to enhance drug development through mechanistic modeling of biological systems. This individual will be responsible for developing and applying models of complex systems such as intracellular signaling pathways and cellular and soluble protein networks in various therapeutic areas including oncology, immune and inflammatory disease, and neurological disorders. The successful candidate will have responsibilities developing QSP models in the context of specific molecule or therapeutic area needs, conducting in silico research to inform project team goals such as target/compound evaluation, biomarker and diagnostic investigation, human protocol determination, and combination therapy identification. Biomarker and diagnostics related investigation will be a significant focus of these efforts. The candidate will also have responsibilities using PKPD modeling and simulation to support large-molecule preclinical and translational efforts, with continued support as needed through approval. Maintaining close and effective partnerships with other preclinical and clinical PK/PD and biomarker scientists, safety scientists, research scientists, clinicians and project teams will be essential. An additional component will be the presentation of results at cross-functional teams, department meetings, review committees, and conferences.
A Ph.D. in Biomedical or Chemical Engineering, Pharmaceutical Sciences, or a related discipline and a proven track record of applying QSP modeling and simulation approaches to biological systems and/or drug development either in industry or academia is required. Proficiency with differential equation and/or logic based modeling is essential, as is experience with relevant software (e.g., MATLAB, R, etc).Experience with modeling and simulation of large molecule PKPD is desirable. Passionate About Our People We recognize that our people are our most important asset. It’s why we foster an inclusive environment that encourages diversity and offer competitive healthcare and benefits to help you bring the best to the business and to your personal life. Join us as we continue to tackle medicine’s most challenging problems and live a life inspired. Apply Below! Now a member of the Roche Group, Genentech has multiple medicines on the market for cancer and other serious illnesses. Genentech is an Equal Opportunity Employer: Minorities/Women/Disability/Veteran. Apply Here: http://www.Click2apply.net/pfy5m2r
South San Francisco, California, 94080
Human Resources
9/10/2014 7:35:42 AM
Details>> Genentech
Associate Scientist/Scientist Preclinical and Translational PK/PD
Passionate About Science We’re passionate and rigorous about our science. For more than 30 years, Genentech has been at the forefront of the biotechnology industry, using innovative science to develop breakthrough medicines that improve the lives of people with serious or life-threatening diseases. The following opportunity exists in our South San Francisco, CA headquarters: Associate Scientist/Scientist Preclinical and Translational PK/PD Responsibilities: The Preclinical and Translational PKPD (PTPK) Department at Genentech, Inc. is seeking an exceptional scientist to support pharmacokinetics and pharmacodynamics programs for novel drug candidates with a focus on protein therapeutics. The candidate will be responsible for investigating the pharmacokinetics, biodistribution, and PKPD relationships of novel therapeutics in preclinical models to identify lead candidates for further development, and for bridging preclinical PKPD information to patients. The candidate will be responsible for supporting preclinical development and first in human regulatory filings, including reviewing PK/PD studies. This will be accomplished by working in close partnerships across various functions including Research, Development Sciences, Clinical Sciences, Biostatistics, and Regulatory. The candidate will represent the department on cross- functional project teams as a PKPD representative.
Requirements: A Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Biomedical Engineering or related discipline is required. The desired candidate should have 2+ years of experience and demonstrated impact on drug development and/or the PKPD scientific landscape. Experience with protein therapeutics and knowledge of ophthalmology and/or neuroscience is desired. Working knowledge of PK/PD software (e.g., WinNonlin, NONMEM, ADAPT II) and the ability to critically assess PK/PD data is necessary. Sufficient industry and/or post-doctoral experience are required. Passionate About Our People We recognize that our people are our most important asset. It’s why we foster an inclusive environment that encourages diversity and offer competitive healthcare and benefits to help you bring the best to the business and to your personal life. Join us as we continue to tackle medicine’s most challenging problems and live a life inspired. Apply Below! Now a member of the Roche Group, Genentech has multiple medicines on the market for cancer and other serious illnesses. Genentech is an Equal Opportunity Employer: Minorities/Women/Disability/Veteran. Apply Here : http://www.Click2apply.net/5grphsv
South San Francisco, California, United States, 94080
Human resources
9/9/2014 2:04:11 PM
Details>> BioSeek a division of DiscoveRx
Senior Research Associate, Immunology
We are seeking a Senior Research Associate for our BioSeek Biology Research group with expertise human primary cell culture and immune cell isolation and characterization. The ideal candidate will have extensive experience in isolating and/or differentiating immune cell subsets from human peripheral blood and have a background in immunology, oncology or respiratory biology. Hands-on experience with evaluation methods including flow cytometry, immunofluorescent or immunohistochemical procedures, microscopy, ELISA or other biochemical and immuno-based analysis of protein biomarker expression is required. The successful candidate will be involved in designing and executing primary human cell-based research projects and subsequent data analysis related to the development of high throughput BioMAP Cell-Based Assays for compound screening. The position also involves cell banking, data management and inventory tracking as well as being part of the quality management program. This candidate will work interactively with multiple departments, so excellent communication skills are essential. POSITION DUTIES AND RESPONSIBILTIES: Primary responsibilities include: • Develop methods to isolate, derive, characterize, qualify, and bank human immune cell types from buffy coats as well as patient-derived samples • Culture and characterize human primary cells, perform biochemical and immuno-based analysis of protein biomarker expression and other standard molecular biological techniques • Participate in the development of in vitro disease models performing a variety of cell-based assays and data analysis, working independently but within a team environment • Maintain laboratory equipment and supplies, assay operations notebooks and computer files • Communicate results and present data at multi-disciplinary project team meetings • Work cooperatively with scientists and personnel in other departments (e.g. Assay Operations and Scientific IT) • Performing other duties as required and assigned
• B.S. and 5+ years or M.S. degree and 3+ years of relevant experience • Comprehensive knowledge of cell culture techniques, including proficiency in maintaining both adherent and suspension mammalian cell cultures and experience in growing human primary cells • Experience in designing, implementing and analyzing cell-based studies using a variety of techniques including ELISA, luminex, flow cytometry, western blotting, microscopic imaging and basic molecular biology techniques such as RT-PCR • Must be able to follow standard operating procedures, make careful observations, and keep clear and complete records of work • Strong verbal and written communication skills • Organized, self-motivated and able to work both independently and as part of a team. • Critical thinking, systematic problem solving skills, and flexibility are strongly desired traits
South San Francisco, CA
Qualified candidates should submit a resume with cover letter to jobs@discoverx.com and reference job code DRx040-2014 in the subject line. No phone calls or in-person inquiries please.
8/26/2014 5:24:04 PM
Details>> BioSeek a division of DiscoveRx
Senior Research Associate, Gene Expression
We are seeking a Senior Research Associate for our BioSeek Biology Research group with expertise in RNA isolation from primary cell culture and gene expression data analysis within a high throughput, drug development environment. The ideal candidate will be a highly motivated, organized and detail-oriented individual with extensive hands-on experience with gene expression and the use of various gene expression analysis platforms, including qPCR, microarray and next-generation sequencing (RNA-Seq). This position will work interactively with multiple departments, so excellent communication skills are essential. POSITION DUTIES AND RESPONSIBILTIES: Primary responsibilities include: • Independent planning, coordination and execution of gene expression analysis studies for internal and external projects; be able to organize, prioritize and manage client-driven timelines and deliverables. • Manage multiple complex gene expression studies including generation and analysis of gene expression experiments. • Performance of preliminary statistical analysis and data qualification for gene expression analysis studies. • Maintenance of laboratory equipment and supplies, electronic lab notebooks and computer files. • Active participation in company-wide research meetings, including making detailed scientific presentations. • Performing other duties as required and assigned.
• B.S. and 5+ years or M.S. degree and 3+ years of relevant experience. • Extensive experience in generating and analyzing gene expression data using multiple platforms. • Experience with cell culture techniques, including proficiency in maintaining both adherent and suspension mammalian cell cultures and in growing primary human cells. • Proficiency with advanced data analysis programs (Spotfire, Partek, JMP genomics or similar) is a plus. • Excellent oral and written communication skills. • The ability to work cross-functionally.
South San Francisco, CA
Qualified candidates should submit a resume with cover letter to jobs@discoverx.com and reference job code DRx039-2014 in the subject line. No phone calls or in-person inquiries please.
8/26/2014 1:31:51 PM
Details>> BioSeek a division of DiscoveRx
Manager, Cell-Based Screening and Automation
We are seeking a highly motivated and team-oriented Manager of Cell-Based Screening and Automation, reporting to the Senior Director of Operations. In this position, you will supervise the operation of cell-based screening platforms in the Assay Operations group. You will lead a group of talented scientists, generating protein biomarker data that support preclinical drug development activities for client pharmaceutical companies, including evaluation of potency and efficacy in human disease model systems, identification of potential clinical biomarkers, and detection of potential off-target effects. You will be working cooperatively in a busy laboratory environment, responding to change with flexibility and adapting quickly to evolving circumstances. This is an excellent opportunity for a team player to lead a multi-disciplinary research/operations group focused on innovating and applying primary human cell-based technologies to the development of novel therapies. POSITION DUTIES AND RESPONSIBILTIES: The successful candidate will be responsible for the day-to-day operation of the Assay Automation group including the HTS laboratory. Duties will include: • Supervising the HTS and Assay Automation groups • Maintaining and developing the automation used for high throughput screening in human cell-based assays • Ensuring client data meet internal QA/QC criteria and are completed on time • Supporting the Research and Development group at BioSeek developing novel disease-focused assays • Evaluating new detection technologies • Identifying and testing new equipment for implementation in the lab • Developing strategies for streamlining work flow and increasing capacity • Tracking historical assay performance metrics • Performing other duties as required and assigned Daily duties include: data analysis and QA/QC; manage HTS laboratory and Assay Automation group; operation of the robotic assay systems; maintenance of new and existing software applications and tools; method development to support cell-based HTS.
QUALIFICATIONS, SKILLS, AND BACKGROUND: • M.S./Ph.D. in biology or chemistry or a related discipline plus at least 8 years of cell-based assay experience in an industrial or academic laboratory setting including microtiter plate assay setup and execution. • Experience with operation, maintenance and programming of laboratory automation equipment in a high throughput screening environment, cell-based assay design, data analysis, and computer programming is essential. • Previous experience supervising laboratory scientific personnel is strongly preferred. • Must be able to lift at least 50 lbs. • Must be able to work independently and have exceptional interpersonal, organizational and communication skills. • Essential techniques include: o Experience with antibody-based detection technologies (ELISA, bead-based detection methods, and/or other multiplexing solutions) and other protein detection technologies. o Hands-on expertise in programming automated robotic workstations. • Additional skills of high value include: o Experience with high-throughput cell-based screening o Experience with antibody production and screening o Solid computer skills (Excel, PowerPoint, database, and statistical programs like Prism)
South San Francisco, CA
Qualified candidates should submit a resume with cover letter to jobs@discoverx.com and reference job code DRx038-2014 in the subject line. No phone calls or in-person inquiries please.
8/26/2014 1:14:16 PM
Details>> Amyris
Scientist, Analytical Development
We are seeking an enthusiastic, team oriented, problem solver to join our Chemical Analytics group. The incumbent will be responsible for leading a team of associate scientists and building relationships to support process development and manufacturing. Specific activities include assay development and qualification, method transfer, product and process characterization. A key component of these activities is translating project goals into analytical methodologies. In addition, responsibilities include oversight of an analytical instrumentation facility made available for use within the team as well as to internal partners. The incumbent will represent progress to internal and external customers on analytical assay development and qualification, testing, and data analysis and will be responsible for preparation of technical reports. The incumbent will report to an Associate Director and will be responsible for the professional development of the team.
• Ph.D degree in analytical chemistry or related discipline with 5+ years’ experience in an analytical laboratory, including 1-2 years’ experience in an industrial setting. • Record of excellent analytical capabilities preferably with such techniques as GC, HPLC, GPC, DSC, TGA, titration, spectroscopy. • Demonstrated ability to translate project goals into analytical methods. • Experience with aspects of method development relevant to manufacturing applications such as GMP/GLP, method qualification and robustness testing, process analytical technologies, method transfer best practices, quality systems, documentation. • Experienced in interfacing with quality teams. • Ability to manage and manipulate large data sets to draw statistically sound conclusions. Experience with DOE, JMP, or similar statistical tools. • Demonstrated supervisory experience (3 yrs. minimum). • Time-management and multi-tasking skills are mandatory. • Teamwork and clear communication skills; ability to effectively interact cross-functionally. • Demonstrated ability to write well. • Committed to promoting a safe work environment. • Energetic, creative and highly self-motivated. • Embrace Amyris Core Values.
Emeryville, CA
https://home.eease.adp.com/recruit2/?id=10513041&t=1
8/25/2014 4:52:41 PM
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